Abstract: Papaya is the first fruit crop which was not only successfully genetically engineered but also deregulated and commercialized. Pathogenic derived resistance was utilized for harnessing PRSV resistance. Coat protein gene from PRSV was invariably used to confer resistance against papaya ring spot virus. Microprojectile transformation has been the most preferred pathway. However, several reports are also available involving Agrobacterium pathway. Majority of workers found somatic embryos as the explant of choice for genetic manipulation in papaya compared to other explants. This paper highlights the global status of development of genetically engineered papaya for viral resistance.